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Build and deploy digital twins of pharmaceutical processes

Learn how Basetwo enables manufacturers to streamline process scale up, maximize yield, and minimize deviations

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Pharma manufacturing involves the complex interaction of several unit operations working collectively at various scales. Regulation of these unit operations enables the production of high-quality products at various stages of production, but requires careful coordination between:

Process Development

Process Development

Commercial manufacturing

Scale Up &
Tech Transfer

cGMP and CMC initiatives process

cGMP & CMC Initiatives

Keep scrolling to see how Basetwo improves efficiencies across the pharma value chain.
Fermentation optimization in bioreactor systemCloud Security

Fermentation Optimization

From benchside to commercial scale, Basetwo enables manufacturers to optimize and understand the mechanisms driving batch, fed-batch, and even continuous bioreactor systems.

Using the Basetwo platform, process engineers can build high-fidelity predictive models to maximize reaction efficiency and understand the influence of process disturbances.

Chromatography Optimization

Chromatography is a high complex unit operation. Using the Basetwo platform, engineers can confidently build and validate digital twins capable of optimizing loading flow rates in various chromatography systems and improve their causal understanding of conditions influencing product yield and quality. Integrated process modeling allows for optimization even in sequential chromatography steps or in continuous systems to optimize purification.

chromatography system line graph


Reducing the energy consumption of distillation is complex due to nonlinearities of upstream process disturbances that influence current operating conditions and process efficiency.

Basetwo’s modeling and optimization capabilities leverage industry-proven methods to accurately predict operating information, enabling engineers to rapidly react to changes in process conditions driven by upstream output or other disturbances.

distillation process
Fermentation process in lab

Technology Transfer & Scale-up

Scaling a process from the benchtop to commercial scale is a significant challenge as process dynamics at the benchside do not always translate to commercial scale or at a different site.

With Basetwo, manufacturers can use process development and commercial data to build a process model that learns how process dynamics change with scale, enabling a more predictable scale-up and tech transfer process to improve time to value and minimize risk.

Resin Lifespan Extension

Resins are a highly costly resource that require regular cleanings and degrade exponentially with use, often leading to suboptimal retiring of columns that can affect product yield and quality.

Using Basetwo, engineering teams can reliably forecast resin performance to enable better cleaning protocols and maximize the lifetime of the resin without compromising performance.

forecasting of resin performance

See how Basetwo can deliver:

Reduction in OPEX
Increase in yield and efficiency
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